Background:

Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms.

Applications:

ELISA, IHC

Name of antibody:

PIK3R1

Immunogen:

Synthetic peptide of human PIK3R1

Full name:

phosphoinositide-3-kinase regulatory subunit 1

Synonyms:

p85; AGM7; GRB1; IMD36; p85-ALPHA

SwissProt:

P27986

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human tonsil

IHC Recommend dilution:

25-100