Background:

This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome.

Applications:

ELISA, IHC

Name of antibody:

NOD2

Immunogen:

Synthetic peptide of human NOD2

Full name:

nucleotide-binding oligomerization domain containing 2

Synonyms：

CD; ACUG; BLAU; IBD1; NLRC2; NOD2B; CARD15; CLR16.3; PSORAS1

SwissProt:

Q9HC29

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human liver cancer and Human thyroid cancer

IHC Recommend dilution:

25-100