Background:

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.

Applications:

WB

Name of antibody:

PDGFRB(Ab-771)

Immunogen:

Synthesized peptide derived from Internal of human PDGFRB.

Full name:

platelet-derived growth factor receptor, beta polypeptide

Synonyms：

IMF1; IBGC4; JTK12; PDGFR; CD140B; PDGFR1; PDGFR-1

SwissProt:

P09619

WB Predicted band size:

124 kDa

WB Positive control:

HepG2 cells lysate

WB Recommended dilution:

500-3000