Background:

The enzyme encoded by this gene catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5'-phosphate, also known as vitamin B6. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine. Mutations in this gene result in pyridoxamine 5'-phosphate oxidase (PNPO) deficiency, a form of neonatal epileptic encephalopathy.

Applications:

ELISA, WB, IHC

Name of antibody:

PNPO

Immunogen:

Synthetic peptide of human PNPO

Full name:

pyridoxamine 5'-phosphate oxidase

Synonyms:

PDXPO; HEL-S-302

SwissProt:

Q9NVS9

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human thyroid cancer; Human gastric cancer

IHC Recommend dilution:

20-100

WB Predicted band size:

30 kDa

WB Positive control:

HepG2, 293T, Hela and PC-3 cell lysates

WB Recommended dilution:

200-1000