Background:

The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency.

Applications:

ELISA, IHC

Name of antibody:

SERPINC1

Immunogen:

Fusion protein of human SERPINC1

Full name:

serpin peptidase inhibitor, clade C (antithrombin), member 1

Synonyms：

AT3, AT3D, ATIII, THPH7

SwissProt:

P01008

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human thyroid cancer and human lung cancer

IHC Recommend dilution:

25-100