Background:

Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1/CDC2 and acts as a key regulator of meiosis during both prophase I and metaphase II (PubMed:29606300). Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation (By similarity).

Applications:

ELISA, IHC

Name of antibody:

WEE2

Immunogen:

Synthetic peptide of human WEE2

Full name:

WEE1 homolog 2

Synonyms:

OOMD5; WEE1B

SwissProt:

P0C1S8

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer and Human colorectal cancer

IHC Recommend dilution:

25-100